Skip to Main content Skip to Navigation
Theses

Full-field optical coherence tomography for non-contact cellular-level resolution in vivo human cornea imaging

Abstract : This PhD project aimed to create an optical system for non-contact cellular resolution imaging of the human cornea in vivo. To achieve that, the contact ex vivo time-domain full-field optical coherence tomography (FFOCT) system was transformed into a non-contact in vivo imaging device and was for the first time applied to the human eye. FFOCT acquired images from the entire human cornea, limbus, sclera and tear film, revealing cells and nerves, which could be quantified over a millimetric field-of-view, beyond the capability of confocal microscopy and conventional optical coherence tomography (OCT). Blood flow and tear film dynamics could be directly followed and quantified. Furthermore, FFOCT was combined with a conventional OCT to perform real-time axial eye tracking and defocusing correction. The latter enabled real-time FFOCT imaging and display, which opens a path for future device implementation in clinical research and practice. Bench to bedside transfer of FFOCT is further stimulated by several solutions proposed in the manuscript, aiming to reduce the instrumentational complexity. Finally, a related FFOCT device was applied to imaging in vivo human retina, revealing the photoreceptors.
Document type :
Theses
Complete list of metadatas

Cited literature [123 references]  Display  Hide  Download

https://pastel.archives-ouvertes.fr/tel-02626956
Contributor : Abes Star :  Contact
Submitted on : Tuesday, May 26, 2020 - 6:32:08 PM
Last modification on : Saturday, September 26, 2020 - 11:44:12 PM

File

ESPCI_ViacheslavMAZLIN_2019.pd...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02626956, version 1

Citation

Viacheslav Mazlin. Full-field optical coherence tomography for non-contact cellular-level resolution in vivo human cornea imaging. Physics [physics]. Université Paris sciences et lettres, 2019. English. ⟨NNT : 2019PSLET024⟩. ⟨tel-02626956⟩

Share

Metrics

Record views

66

Files downloads

115