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Polymersomes stimulables à base de polypeptoids

Abstract : The self-assembly of amphiphilic block copolymers has been a hot issue for many years, and among them the self-assembled polymer vesicle, namely polymersome, has attracted much attention with its similar structure to cellular membrane and great potential in biomedial field. Hence we come up with an idea to combine the special liquid crystal (LC) layer structure with the novel ring-opening polymerization, in order to develop a new type of polymersomes with biocompatibility and stimuli-responsiveness. The research project includes the following aspects: (1) Synthesize different kinds of PSar-containing LC copolymers with clear structure characterization data; (2)Analyze the relationship between the self-assembly behavior and structure of the synthesized copolymers, obtain the condition for polymersome formation from the copolymers, and find out the formative mechanism; (3) Prepare stimuli-responsive and targeting polymersomes with additional chemical modification, and study their responsiveness in function of oxidation-reduction, pH, temperature, magnetic field,light etc.
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Yangwei Deng. Polymersomes stimulables à base de polypeptoids. Polymères. Université Paris sciences et lettres, 2018. Français. ⟨NNT : 2018PSLEC021⟩. ⟨tel-02861912⟩

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