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Theses

Développement d’un filtre spectral ultra résolu pour l’imagerie acousto-optique

Abstract : Optical imaging for Medicine is limited by the spatial resolution loss due to light scattering in turbid media. A hybrid imaging method called ultrasound optical tomography can overcome this botteneck. Indeed the simultaneous use of light and ultrasound gives access to optical contrast in depth within scattering medium with the ultrasounds resolution. Several interferometric methods have been developed in order to detect an acousto-optic signal. However, none of them is adapted to in vivo imaging. For this reason a filter created with spectral hole burning is of special interest. This thesis presents the development of an ultra-narrow filter based on spectral hole burning in a thulium doped yttrium aluminum garnet crystal (Tm:YAG) under magnetic field. The first part of the manuscript describes the characterization of the filter in the imaging setup. Next, the actual imaging of a scattering gel is described. The following part presents the change of the main laser and its frequency stabilization for technological maturation. The last part of the manuscript details how the experiment have been compacted to be bring in a pharmacetical laboratory in order to launch in vivo imaging trials.
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Caroline Venet. Développement d’un filtre spectral ultra résolu pour l’imagerie acousto-optique. Optique [physics.optics]. Université Paris sciences et lettres, 2019. Français. ⟨NNT : 2019PSLET066⟩. ⟨tel-02929318⟩

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