, Cas de TIA en région Provence-Alpes-Côte d'Azur et en Occitanie entre janvier 2011 et mars 2014, associés à la consommation de violets RÉFÉRENCES BIBLIOGRAPHIQUES, Tableau, vol.34

J. Aasen, S. L. Mackinnon, P. Leblanc, J. A. Walter, P. Hovgaard et al., Detection and identification of spirolides in Norwegian shellfish and plankton, Chemical Research in Toxicology, vol.18, issue.3, pp.509-515, 2005.

J. Aasen, I. A. Samdal, C. O. Miles, E. Dahl, L. R. Briggs et al., Yessotoxins in Norwegian blue mussels (Mytilus edulis): uptake from Protoceratium reticulatum, metabolism and depuration, Toxicon, vol.45, issue.3, pp.265-272, 2005.

A. Abraham, E. L. Jester, H. R. Granade, S. M. Plakas, and R. W. Dickey, Caribbean ciguatoxin profile in raw and cooked fish implicated in ciguatera, Food Chemistry, vol.131, issue.1, pp.192-198, 2012.

A. Agüera, M. J. Bueno, and A. R. Fernández-alba, New trends in the analytical determination of emerging contaminants and their transformation products in environmental waters, Environmental Science and Pollution Research, vol.20, issue.6, pp.3496-3515, 2013.

L. Ahrens and M. Bundschuh, Fate and effects of poly-and perfluoroalkyl substances in the aquatic environment: A review, Environmental Toxicology and Chemistry, vol.33, issue.9, pp.1921-1929, 2014.

K. Aligizaki, P. Katikou, G. Nikolaidis, and A. Panou, First episode of shellfish contamination by palytoxin-like compounds from Ostreopsis species, Toxicon, vol.51, issue.3, pp.418-427, 2008.

Z. Amzil, Y. F. Pouchus, J. Le-boterff, C. Roussakis, J. Verbist et al., Short-time cytotoxicity of mussel extracts: A new bioassay for okadaic acid detection, Toxicon, vol.30, issue.11, pp.1419-1425, 1992.

Z. Amzil, M. Sibat, N. Chomerat, H. Grossel, F. Marco-miralles et al., Ovatoxin-a and Palytoxin Accumulation in Seafood in Relation to Ostreopsis cf. ovata Blooms on the French Mediterranean Coast, Marine Drugs, vol.10, issue.2, p.477, 2012.

Z. Amzil, M. Sibat, F. Royer, N. Masson, and E. Abadie, Report on the first detection of pectenotoxin-2, spirolide-A and their derivatives in French shellfish, Marine Drugs, vol.5, issue.4, pp.168-179, 2007.

G. L. Andrews, B. L. Simons, J. B. Young, A. M. Hawkridge, and D. C. Muddiman, Performance Characteristics of a New Hybrid Quadrupole Time-of-Flight Tandem Mass Spectrometer (TripleTOF 5600), Analytical Chemistry, vol.83, issue.13, pp.5442-5446, 2011.

. Anonyme, Directive 91/492/CEE du Conseil du 15 juillet 1991 fixant les règles sanitaires régissant la production et la mise sur le marché de mollusques bivalves vivants Journal officiel de l'Union Européenne L 268, p.14, 1991.

. Anonyme, Règlement (CE) N°853/2004 du Parlement Européen et du Conseil du 29 avril 2004 fixant des règles spécifiques d'hygiène applicables aux denrées alimentaires d'origine animale, Journal, p.151, 2004.

. Anonyme, Règlement (CE) N°854/2004 du Parlement Européen et du Conseil du 29 avril 2004 fixant les règles spécifiques d'organisation des contrôles officiels concernant les produits d'origine animale destinés à la consommation humaine, Journal, p.45, 2004.

. Anonyme, Règlement (CE) No 1244/2007 de la Commission du 24 octobre 2007 modifiant le règlement (CE) no 2074/2005 en ce qui concerne les mesures d'application relatives à certains produits d'origine animale destinés à la consommation humaine et établissant des règles spécifiques concernant les contrôles officiels relatifs à l'inspection des viandes, 2007.

. Anonyme, Règlement (UE) N° 15/2011 de la Commission du 10 janvier 2011 modifiant le règlement (CE) n o 2074/2005 en ce qui concerne les méthodes d'analyse reconnues des biotoxines marines chez les mollusques bivalves vivants, Journal, 2011.

. Anonyme, Règlement (UE) N° 786/2013 de la Commission du 16 août 2013 modifiant l'annexe III du règlement (CE) N° 853/2004 du Parlement Européen et du Conseil en ce qui concerne les limites autorisées de yessotoxines dans les mollusques bivalves vivants, Journal, 2013.

. Anonyme, Réglement (UE) 2017/1980 de la Commission du 31 octobre 2017 modifiant l'annexe III du règlement (CE) N° 2074/2005 en ce qui concerne la méthode de détection des toxines paralysantes (paralytic shellfish poison -PSP), Journal, 2017.

. Anonymous, Molecular Components Map of Representative Matrices of Commodity Groups in document SANTE/11813/2017, p.29, 2018.

. Anses, Guide de validation des méthodes d'analyses, p.67, 2015.

A. Apffel, S. Fischer, G. Goldberg, P. C. Goodley, and F. E. Kuhlmann, Enhanced sensitivity for peptide mapping with electrospray liquid chromatography-mass spectrometry in the presence of signal suppression due to trifluoroacetic acid-containing mobile phases, Journal of Chromatography A, vol.712, issue.1, pp.177-190, 1995.

D. G. Baden, A. J. Bourdelais, H. Jacocks, S. Michelliza, and J. Naar, Natural and derivative brevetoxins: historical background, multiplicity, and effects, Environmental health perspectives, vol.113, issue.5, pp.621-625, 2005.

V. Bane, S. Hutchinson, A. Sheehan, B. Brosnan, P. Barnes et al., LC-MS/MS method for the determination of tetrodotoxin (TTX) on a triple quadruple mass spectrometer. Food Additives and Contaminants -Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, vol.33, issue.11, pp.1728-1740, 2016.

V. Bane, M. Lehane, M. Dikshit, . #039, A. Riordan et al., Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection, Toxins, vol.6, issue.2, p.693, 2014.

S. Banzhaf, M. Filipovic, J. Lewis, C. J. Sparrenbom, and R. Barthel, A review of contamination of surface-, ground-, and drinking water in Sweden by perfluoroalkyl and polyfluoroalkyl substances (PFASs), Ambio, vol.46, issue.3, pp.335-346, 2017.

E. Barbaro, R. Zangrando, S. Rossi, W. R. Cairns, R. Piazza et al., Domoic acid at trace levels in lagoon waters: Assessment of a method using internal standard quantification, Analytical and Bioanalytical Chemistry, vol.405, issue.28, pp.9113-9123, 2013.

S. Bates and T. V. , The ecology of harmful diatoms, Ecology on Harmful Algae, p.189, 2006.

R. Biré, S. Krys, J. M. Frémy, and S. Dragacci, Improved Solid-Phase Extraction Procedure in the Analysis of Paralytic Shellfish Poisoning Toxins by Liquid Chromatography with Fluorescence Detection, Journal of Agricultural and Food Chemistry, vol.51, issue.22, pp.6386-6390, 2003.

R. Biré, S. Krys, J. M. Frémy, S. Dragacci, D. Stirling et al., First evidence on occurrence of gymnodimine in clams from Tunisia, Journal of Natural Toxins, vol.11, issue.4, pp.269-275, 2002.

R. Biré, S. Trotereau, R. Lemée, C. Delpont, B. Chabot et al., Occurrence of palytoxins in marine organisms from different trophic levels of the French Mediterranean coast harvested in 2009, Harmful Algae, vol.28, pp.10-22, 2013.

R. Biré, S. Trotereau, R. Lemée, D. Oregioni, C. Delpont et al., Hunt for palytoxins in a wide variety of marine organisms harvested in 2010 on the French Mediterranean coast, Marine Drugs, vol.13, issue.8, pp.5425-5446, 2015.

P. Blay, J. P. Hui, J. Chang, and J. E. Melanson, Screening for multiple classes of marine biotoxins by liquid chromatography-high-resolution mass spectrometry, Analytical and Bioanalytical Chemistry, vol.400, issue.2, pp.577-585, 2011.

L. D. Boada, M. Zumbado, O. P. Luzardo, M. Almeida-gonzález, S. M. Plakas et al., Ciguatera fish poisoning on the West Africa Coast: An emerging risk in the Canary Islands (Spain), Toxicon, vol.56, issue.8, pp.1516-1519, 2010.

L. M. Botana and A. Alfonso, Phycotoxins: Chemistry and Biochemistry: Second Edition, 2015.

M. Y. Bottein, L. Kashinsky, Z. Wang, C. Littnan, and J. S. Ramsdell, Identification of ciguatoxins in Hawaiian monk seals Monachus schauinslandi from the Northwestern and Main Hawaiian Islands, Environ Sci Technol, vol.45, issue.12, pp.5403-5409, 2011.

S. Boudah, M. Olivier, S. Aros-calt, L. Oliveira, F. Fenaille et al., Annotation of the human serum metabolome by coupling three liquid chromatography methods to high-resolution mass spectrometry, Journal of Chromatography B, vol.966, pp.34-47, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01664192

M. J. Boundy, A. I. Selwood, D. T. Harwood, P. S. Mcnabb, and A. D. Turner, Development of a sensitive and selective liquid chromatography-mass spectrometry method for high throughput analysis of paralytic shellfish toxins using graphitised carbon solid phase extraction, Journal of Chromatography A, vol.1387, pp.1-12, 2015.

A. Braña-magdalena, J. M. Leão-martins, T. Glauner, and A. Gago-martínez, Intralaboratory validation of a fast and sensitive UHPLC/MS/MS method with fast polarity switching for the analysis of lipophilic shellfish toxins, Journal of AOAC International, vol.97, issue.2, pp.285-292, 2014.

C. Brissard, C. Herrenknecht, V. Séchet, F. Hervé, F. Pisapia et al., Complex toxin profile of French Mediterranean Ostreopsis cf. ovata strains, seafood accumulation and ovatoxins prepurification, Marine Drugs, vol.12, issue.5, pp.2851-2876, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01330182

C. Brissard, C. Herrenknecht, V. Séchet, F. Hervé, F. Pisapia et al., Complex Toxin Profile of French Mediterranean Ostreopsis cf. ovata Strains, Seafood Accumulation and Ovatoxins Prepurification, Marine Drugs, vol.12, issue.5, p.2851, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01330182

B. Buszewski and S. Noga, Hydrophilic interaction liquid chromatography (HILIC)-a powerful separation technique, Analytical and Bioanalytical Chemistry, vol.402, issue.1, pp.231-247, 2012.

A. Caillaud, P. De-la-iglesia, E. Barber, H. Eixarch, N. Mohammad-noor et al., Monitoring of dissolved ciguatoxin and maitotoxin using solid-phase adsorption toxin tracking devices: Application to Gambierdiscus pacificus in culture, Harmful Algae, vol.10, pp.433-446, 2011.

A. Caillaud, P. De-la-iglesia, H. T. Darius, S. Pauillac, K. Aligizaki et al., Update on methodologies available for ciguatoxin determination: Perspectives to confront the onset of ciguatera fish poisoning in Europe, Marine Drugs, vol.8, issue.6, pp.1838-1907, 2010.

L. Cassiday, First report of TTX in a European trumpet shell, Analytical Chemistry, vol.80, issue.15, pp.5675-5675, 2008.

M. Castro-puyana, R. Pérez-míguez, L. Montero, and M. Herrero, Reprint of: Application of mass spectrometry-based metabolomics approaches for food safety, quality and traceability, TrAC Trends in Analytical Chemistry, vol.96, pp.62-78, 2017.

A. D. Cembella, N. I. Lewis, and M. A. Quilliam, The marine dinoflagellate Alexandrium ostenfeldii (Dinophyceae) as the causative organism of spirolide shellfish toxins, Phycologia, vol.39, issue.1, pp.67-74, 2000.

J. Chen, L. Gao, Z. Li, S. Wang, J. Li et al., Simultaneous screening for lipophilic and hydrophilic toxins in marine harmful algae using a serially coupled reversed-phase and hydrophilic interaction liquid chromatography separation system with high-resolution mass spectrometry, Analytica Chimica Acta, 2016.

M. Chinain, C. Gatti, M. Roué, D. Laurent, and H. T. Darius, Ciguatéra : aspects écologiques, biologiques et toxicologiques. Revue Francophone des Laboratoires, pp.27-39, 2014.

P. Ciminiello, C. Dell'aversano, E. Dello-iacovo, M. Forino, and L. Tartaglione, Liquid chromatography-high-resolution mass spectrometry for palytoxins in mussels, Analytical and Bioanalytical Chemistry, vol.407, issue.5, pp.1463-1473, 2015.

P. Ciminiello, C. Dell'aversano, E. Fattorusso, M. Forino, L. Grauso et al., A 4-decade-long (and still ongoing) hunt for palytoxins chemical architecture, Toxicon, vol.57, issue.3, pp.362-367, 2011.

P. Ciminiello, C. Dell'aversano, E. Fattorusso, M. Forino, G. S. Magno et al., The Genoa 2005 outbreak. Determination of putative palytoxin in mediterranean Ostreopsis ovata by a new liquid chromatography tandem mass spectrometry method, Analytical Chemistry, vol.78, issue.17, pp.6153-6159, 2006.

P. Ciminiello, C. Dell'aversano, E. Fattorusso, M. Forino, G. S. Magno et al., Hydrophilic interaction liquid chromatography/mass spectrometry for determination of domoic acid in Adriatic shellfish, Rapid Communications in Mass Spectrometry, vol.19, issue.14, pp.2030-2038, 2005.

P. Ciminiello, C. Dell'aversano, E. D. Iacovo, E. Fattorusso, M. Forino et al., Complex palytoxin-like profile of Ostreopsis ovata. Identification of four new ovatoxins by high-resolution liquid chromatography/mass spectrometry, Rapid Communications in Mass Spectrometry, vol.24, issue.18, pp.2735-2744, 2010.

P. Ciminiello, C. Dell'aversano, E. D. Iacovo, E. Fattorusso, M. Forino et al., LC-MS of palytoxin and its analogues: State of the art and future perspectives, Toxicon, vol.57, issue.3, pp.376-389, 2011.

J. Clayden, B. Read, and K. R. Hebditch, Chemistry of domoic acid, isodomoic acids, and their analogues, Tetrahedron, vol.61, issue.24, pp.5713-5724, 2005.

R. D. Combes, The mouse bioassay for diarrhetic shellfish poisoning: a gross misuse of laboratory animals and of scientific methodology, Altern Lab Anim, vol.31, issue.6, pp.595-610, 2003.

J. Cotton, F. Leroux, S. Broudin, M. Poirel, B. Corman et al., Development and validation of a multiresidue method for the analysis of more than 500 pesticides and drugs in water based on on-line and liquid chromatography coupled to high resolution mass spectrometry, Water Research, vol.104, pp.20-27, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01608514

E. E. Creppy, A. Traoré, I. Baudrimont, M. Cascante, and M. Carratú, Recent advances in the study of epigenetic effects induced by the phycotoxin okadaic acid, Toxicology, vol.181, pp.433-439, 2002.

M. Daneshian, L. M. Botana, M. Y. Bottein, G. Buckland, M. Campàs et al., T4 Report: A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems, Altex, vol.30, issue.4, pp.487-545, 2013.

J. De-fouw, H. Van-egmond, and G. Speijers, Ciguatera fish poisoning: a review, Ciguatera visvergiftiging, p.66, 2001.

,. Dechraoui-bottein, Z. Wang, and J. S. Ramsdell, Toxicokinetics of the ciguatoxin P-CTX-1 in rats after intraperitoneal or oral administration, Toxicology, vol.284, issue.1-3, pp.1-6, 2011.

J. Deeds, J. Landsberg, S. Etheridge, G. Pitcher, and S. Longan, Non-Traditional Vectors for Paralytic Shellfish Poisoning, Marine Drugs, vol.6, issue.2, p.308, 2008.

C. Dell'aversano, P. Hess, and M. A. Quilliam, Hydrophilic interaction liquid chromatographymass spectrometry for the analysis of paralytic shellfish poisoning (PSP) toxins, Journal of Chromatography A, vol.1081, issue.2, pp.190-201, 2005.

C. Dell'aversano, P. Hess, and M. A. Quilliam, Hydrophilic interaction liquid chromatographymass spectrometry for the analysis of paralytic shellfish poisoning (PSP) toxins, Journal of Chromatography A, vol.1081, issue.2, pp.190-201, 2005.

R. Dickey, Ciguatera toxins: chemistry, toxicology, and detection. Seafood and Freshwater toxins: Pharmacology, Physiology and Detection, Ed Botana LM, pp.479-500, 2008.

J. Diogène, L. Reverté, M. Rambla-alegre, V. Del-rió, P. De-la-iglesia et al., Identification of ciguatoxins in a shark involved in a fatal food poisoning in the Indian Ocean, Scientific Reports, vol.7, issue.1, 2017.

A. Domènech, N. Cortés-francisco, O. Palacios, J. M. Franco, P. Riobó et al., Determination of lipophilic marine toxins in mussels. Quantification and confirmation criteria using high resolution mass spectrometry, Journal of Chromatography A, vol.1328, pp.16-25, 2014.

R. Draisci, E. Ferretti, L. Palleschi, C. Marchiafava, R. Poletti et al., High levels of yessotoxin in mussels and presence of yessotoxin and homoyessotoxin in dinoflagellates of the Adriatic Sea, Toxicon, vol.37, issue.8, pp.1187-1193, 1999.

, Marine biotoxins in shellfish -Okadaic acid and analogues, scientific opinion of the panel on contaminants in the food chain, EFSA Journal, issue.589, pp.1-62, 2008.

, Marine biotoxins in shellfish -Domoic acid, EFSA Journal, vol.1181, pp.1-61, 2009.

, Scientific opinion on marine biotoxins in shellfish -palytoxin group, EFSA J, vol.7, issue.12, pp.1393-1430, 2009.

. Efsa, Scientific Opinion on marine biotoxins in shellfish -Emerging toxins: Brevetoxin group, EFSA Journal, vol.8, issue.7, p.29, 2010.

A. Elgarch, P. Vale, S. Rifai, and A. Fassouane, Detection of Diarrheic Shellfish Poisoning and Azaspiracids Toxins in Moroccan Mussels: Comparison of LC-MS Method with the Commercial Immunoassay Kit, Marine Drugs, vol.6, issue.4, p.587, 2008.

A. Elgarch, P. Vale, S. Rifai, and A. Fassouane, Detection of Diarrheic Shellfish Poisoning and Azaspiracids Toxins in Moroccan Mussels: Comparison of LC-MS Method with the Commercial Immunoassay Kit, Marine Drugs, vol.6, issue.4, pp.587-594, 2008.

. Fao, Marine biotoxins. FAO Food and Nutrition Paper 80, p.280, 2004.

F. Farabegoli, L. Blanco, L. P. Rodríguez, J. Vieites, and A. García-cabado, Phycotoxins in marine shellfish: Origin, occurrence and effects on humans, Marine Drugs, vol.16, issue.6, 2018.

A. V. Farooq, A. G. Gibbons, M. D. Council, G. J. Harocopos, S. Holland et al., Corneal Toxicity Associated With Aquarium Coral Palytoxin, Am. J. Ophthalmol, vol.174, pp.119-125, 2017.

I. Ferrer and E. M. Thurman, Liquid chromatography/time-of-flight/mass spectrometry (LC/TOF/MS) for the analysis of emerging contaminants, TrAC Trends in Analytical Chemistry, vol.22, issue.10, pp.750-756, 2003.

O. Fiehn, S. P. Putri, K. Saito, R. M. Salek, and D. J. Creek, Metabolomics continues to expand: highlights from the 2015 metabolomics conference, Metabolomics, vol.11, issue.5, pp.1036-1040, 2015.

F. A. Fuhrman, Tetrodotoxin, Tarichatoxin, and Chiriquitoxin: Historical Perspectives, pp.1-14, 1986.

A. Furey, J. Crowley, B. Hamilton, M. Lehane, and K. J. James, Strategies to avoid the misidentification of anatoxin-a using mass spectrometry in the forensic investigation of acute neurotoxic poisoning, Journal of Chromatography A, vol.1082, issue.1, pp.91-97, 2005.

L. F. Gainey and . Jr, A compendium of the responses of bivalve molluscs to toxic dinoflagellate, J. Shellfish Res, vol.7, pp.623-628, 1998.

X. Gao, Q. Zhang, D. Meng, G. Isaac, R. Zhao et al., A reversed-phase capillary ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method for comprehensive top-down/bottom-up lipid profiling, Analytical and Bioanalytical Chemistry, vol.402, issue.9, pp.2923-2933, 2012.

E. García-mendoza, Y. A. Sánchez-bravo, A. Turner, J. Blanco, A. O'neil et al., Lipophilic toxins in cultivated mussels, Toxicon, vol.90, pp.111-123, 2014.

C. García, D. Truan, L. Santelices, J. Díaz, J. C. et al., Metabolic transformation of dinophysistoxin-3 into dinophysistoxin-1 causes human intoxication by consumption of O-acyl-derivatives dinophysistoxins contaminated shellfish, The Journal of Toxicological Sciences, vol.30, p.9, 2005.

A. Gerssen and M. D. Klijnstra, The Determination of Marine Biotoxins in Seafood, Analysis of Food Toxins and Toxicants, pp.321-362, 2017.

A. Gerssen, P. P. Mulder, M. A. Mcelhinney, and J. De-boer, Liquid chromatography-tandem mass spectrometry method for the detection of marine lipophilic toxins under alkaline conditions, JOURNAL OF CHROMATOGRAPHY A, vol.1216, issue.9, pp.1421-1430, 2009.

A. Gerssen, E. H. Van-olst, P. P. Mulder, and J. De-boer, In-house validation of a liquid chromatography tandem mass spectrometry method for the analysis of lipophilic marine toxins in shellfish using matrix-matched calibration, Analytical and Bioanalytical Chemistry, vol.397, issue.7, pp.3079-3088, 2010.

A. V. González, M. L. Rodríguez-velasco, B. Ben-gigirey, and L. M. Botana, First evidence of spirolides in Spanish shellfish, Toxicon, vol.48, issue.8, pp.1068-1074, 2006.

E. Gorrochategui, J. Jaumot, S. Lacorte, and R. Tauler, Data analysis strategies for targeted and untargeted LC-MS metabolomic studies: Overview and workflow, TrAC -Trends in Analytical Chemistry, vol.82, pp.425-442, 2016.

C. Gossner, ,. Schlundt, J. Embarek, P. B. Hird, S. Lo-fo-wong et al., The Melamine Incident: Implications for International Food and Feed Safety, Environmental Health Perspectives, vol.117, issue.12, pp.1803-1808, 2009.

H. R. Granade, F. A. Bencsath, and R. W. Dickey, Isolation of analogues of okadaic acid from cultures of Prorocentrum lima. Bulletin de la Societe de pathologie exotique, pp.478-480, 1990.

K. E. Gribble, B. A. Keafer, M. A. Quilliam, A. D. Cembella, D. M. Kulis et al., Distribution and toxicity of Alexandrium ostenfeldii (Dinophyceae) in the Gulf of Maine, USA. Deep Sea Research Part II: Topical Studies in Oceanography, vol.52, issue.19, pp.2745-2763, 2005.

T. Guardian, Aldi pulls Dutch eggs in Germany as insecticide scandal widens, 2017.

S. Å. Gustavsson, J. Samskog, K. E. Markides, and B. Långström, Studies of signal suppression in liquid chromatography-electrospray ionization mass spectrometry using volatile ionpairing reagents, Journal of Chromatography A, vol.937, issue.1, pp.41-47, 2001.

G. M. Hallegraeff, Ocean climate change, phytoplankton community responses and harmful algal blooms: a formidable predictive challenge, Journal of Phycology, vol.46, issue.2, pp.220-235, 2010.

M. Halme, M. Rapinoja, M. Karjalainen, and P. Vanninen, Verification and quantification of saxitoxin from algal samples using fast and validated hydrophilic interaction liquid chromatography-tandem mass spectrometry method, Journal of Chromatography B, vol.880, pp.50-57, 2012.

B. Hamilton, M. Hurbungs, A. Jones, and R. J. Lewis, Multiple ciguatoxins present in Indian Ocean reef fish, Toxicon, vol.40, issue.9, pp.1347-1353, 2002.

B. Hamilton, N. Whittle, G. Shaw, G. Eaglesham, M. R. Moore et al., Human fatality associated with Pacific ciguatoxin contaminated fish, Toxicon, vol.56, issue.5, pp.668-673, 2010.

K. Harju, M. L. Rapinoja, M. A. Avondet, W. Arnold, M. Schär et al., Optimization of sample preparation for the identification and quantification of saxitoxin in proficiency test mussel sample using liquid chromatography-tandem mass spectrometry, Toxins, vol.7, issue.12, pp.4868-4880, 2015.

P. Hemström and K. Irgum, Hydrophilic interaction chromatography, Journal of Separation Science, vol.29, issue.12, pp.1784-1821, 2006.

P. Hess and J. A. Aasen, Chemistry, Origins, and Distribution of Yessotoxin and its Analogues, pp.187-202, 2007.

P. Hess, E. Abadie, F. Hervé, T. Berteaux, V. Séchet et al., Pinnatoxin G is responsible for atypical toxicity in mussels (Mytilus galloprovincialis) and clams (Venerupis decussata) from Ingril, a French Mediterranean lagoon, Toxicon, vol.75, pp.16-26, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00919909

P. Hess, B. Grune, D. B. Anderson, T. Aune, L. M. Botana et al., Three Rs approaches in marine biotoxin testing, ATLA-Alternatives to Lab Animals, vol.34, p.32, 2006.

P. Hess, L. Nguyen, J. Aasen, M. Keogh, J. Kilcoyne et al., Tissue distribution, effects of cooking and parameters affecting the extraction of azaspiracids from mussels, Mytilus edulis, prior to analysis by liquid chromatography coupled to mass spectrometry, Toxicon, vol.46, issue.1, pp.62-71, 2005.

M. J. Holmes and S. L. Teo, Toxic marine dinoflagellates in Singapore waters that cause seafood poisonings, Clinical and Experimental Pharmacology and Physiology, vol.29, issue.9, pp.829-836, 2002.

V. Hossen, L. Soliño, P. Leroy, E. David, P. Velge et al., Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies), Environmental Research, vol.143, pp.100-108, 2015.

H. Hotelling, Analysis of a complex of statistical variables into principal components, Journal of Educational Psychology, vol.24, issue.6, pp.417-441, 1933.

T. Hu, I. W. Burton, A. D. Cembella, J. M. Curtis, M. A. Quilliam et al., Characterization of spirolides A, C, and 13-desmethyl C, new marine toxins isolated from toxic plankton and contaminated shellfish, Journal of Natural Products, vol.64, issue.3, pp.308-312, 2001.

T. Hu, J. M. Curtis, J. A. Walter, J. L. Mclachlan, and J. L. Wright, Two new water-soluble dsp toxin derivatives from the dinoflagellate prorocentrum maculosum: possible storage and excretion products, Tetrahedron Letters, vol.36, issue.51, pp.9273-9276, 1995.

T. Hu, J. Doyle, D. Jackson, J. Marr, E. Nixon et al., Isolation of a New Diarrhetic Shellfish Poison from Irish Mussels, J. Chem. Soc., Chem. Commun, vol.1, pp.39-41, 1992.

Y. Hua and R. B. Cole, Electrospray ionization tandem mass spectrometry for structural elucidation of protonated brevetoxins in red tide algae, Analytical Chemistry, vol.72, issue.2, pp.376-383, 2000.

B. Huang, Z. Han, Z. Cai, Y. Wu, and Y. Ren, Simultaneous determination of aflatoxins B1, B2, G1, G2, M1 and M2 in peanuts and their derivative products by ultra-high-performance liquid chromatography-tandem mass spectrometry, Analytica Chimica Acta, vol.662, issue.1, pp.62-68, 2010.

A. Ibrahim and W. T. Shier, Editorial Review: Palytoxin: Mechanism of Action of a Potent Marine Toxin, Journal of Toxicology: Toxin Reviews, vol.6, issue.2, pp.159-187, 1987.

H. Ishida, A. Nozawa, H. Nukaya, and K. Tsuji, Comparative concentrations of brevetoxins PbTx-2, PbTx-3, BTX-B1 and BTX-B5 in cockle, Austrovenus stutchburyi, greenshell mussel, Perna canaliculus, and Pacific oyster, Crassostrea gigas, involved neurotoxic shellfish poisoning in New Zealand, Toxicon, vol.43, issue.7, pp.779-789, 2004.

F. Iverson, J. Truelove, E. Nera, L. Tryphonas, J. Campbell et al., Domoic acid poisoning and mussel-associated intoxication: Preliminary investigations into the response of mice and rats to toxic mussel extract, Food and Chemical Toxicology, vol.27, issue.6, pp.377-384, 1989.

K. J. James, M. J. Fidalgo-sáez, A. Furey, and M. Lehane, Azaspiracid poisoning, the food-borne illness associated with shellfish consumption, Food Additives & Contaminants, vol.21, issue.9, pp.879-892, 2004.

K. J. James, M. Gillman, M. F. Amandi, A. López-rivera, P. F. Puente et al., Amnesic shellfish poisoning toxins in bivalve molluscs in Ireland, Toxicon, vol.46, issue.8, pp.852-858, 2005.

K. J. James, C. Moroney, C. Roden, M. Satake, T. Yasumoto et al., Ubiquitous 'benign' alga emerges as the cause of shellfish contamination responsible for the human toxic syndrome, azaspiracid poisoning, Toxicon, vol.41, issue.2, pp.145-151, 2003.

T. Jauffrais, J. Kilcoyne, V. Séchet, C. Herrenknecht, P. Truquet et al., Production and isolation of azaspiracid-1 and -2 from Azadinium spinosum culture in pilot scale photobioreactors, Marine Drugs, vol.10, issue.6, pp.1360-1382, 2012.

H. C. Jen, T. A. Nguyen, Y. J. Wu, T. Hoang, O. Arakawa et al., Tetrodotoxin and paralytic shellfish poisons in gastropod species from Vietnam analyzed by high-performance liquid chromatography and liquid chromatographytandem mass spectrometry, Journal of Food and Drug Analysis, 2013.

K. G. Joreskog, The ML and PLS techniques for modeling with latent variables : Historical and comparative aspects. Systems under Indirect Observation, Part I, pp.263-270, 1982.

C. Junot, L'analyse métabolomique par spectrométrie de masse: un nouvel outil pour la biochimie clinique ? Bio tribune magazine, vol.34, pp.10-15, 2010.

C. Y. Kao, Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena, Pharmacological Reviews, vol.18, issue.2, pp.997-1049, 1966.

M. Katajamaa and M. Ore?i?, Processing methods for differential analysis of LC/MS profile data, BMC Bioinformatics, vol.6, issue.1, p.179, 2005.

A. S. Kerbrat, Z. Amzil, R. Pawlowiez, S. Golubic, M. Sibat et al., First evidence of palytoxin and 42-hydroxy-palytoxin in the marine cyanobacterium Trichodesmium, Mar Drugs, vol.9, issue.4, pp.543-560, 2011.

J. Kilcoyne and E. Fux, Strategies for the elimination of matrix effects in the liquid chromatography tandem mass spectrometry analysis of the lipophilic toxins okadaic acid and azaspiracid-1 in molluscan shellfish, JOURNAL OF CHROMATOGRAPHY A, vol.1217, issue.45, pp.7123-7130, 2010.

J. J. Kirkland, Development of some stationary phases for reversed-phase HPLC, Journal of Chromatography A, vol.1060, issue.1, pp.9-21, 2004.

M. Krauss, H. Singer, and J. Hollender, LC-high resolution MS in environmental analysis: from target screening to the identification of unknowns, Analytical and Bioanalytical Chemistry, vol.397, issue.3, pp.943-951, 2010.

B. Krock, C. G. Seguel, and A. D. Cembella, Toxin profile of Alexandrium catenella from the Chilean coast as determined by liquid chromatography with fluorescence detection and liquid chromatography coupled with tandem mass spectrometry, Harmful Algae, vol.6, issue.5, pp.734-744, 2007.

P. Krogh, Measurements of paralytic shellfish poisons. A review of biological and chemical procedures, Nord Vet Med, vol.31, issue.7-8, pp.302-308, 1979.

S. Krys and J. Frémy, Phycotoxines et produits de la mer: risques sanitaires associés et mesures de prévention. Revue Française des Laboratoires, pp.29-38, 2002.

M. Kunzelmann, M. Winter, M. Aberg, K. E. Hellenas, and J. Rosen, Non-targeted analysis of unexpected food contaminants using LC-HRMS, Anal Bioanal Chem, vol.410, issue.22, pp.5593-5602, 2018.

J. Lago, L. P. Rodriguez, L. Blanco, J. M. Vieites, and A. G. Cabado, Tetrodotoxin, an extremely potent marine neurotoxin: Distribution, toxicity, origin and therapeutical uses, Marine Drugs, vol.13, issue.10, pp.6384-6406, 2015.

N. Lagos, H. Onodera, P. A. Zagatto, D. Andrinolo, S. M. Azevedo et al., The first evidence of paralytic shellfish toxins in the freshwater cyanobacterium Cylindrospermopsis raciborskii, isolated from Brazil, Toxicon, vol.37, issue.10, pp.1359-1373, 1999.

L. Boucher, C. Courant, F. Royer, A. Jeanson, S. Lortal et al., LC-HRMS fingerprinting as an efficient approach to highlight fine differences in cheese metabolome during ripening, Metabolomics, vol.11, issue.5, pp.1117-1130, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01209768

S. Lenoir, L. Ten-hage, J. Turquet, J. Quod, C. Bernard et al., First evidence of palytoxin analogues from an Ostreopsis mascarensis (Dinophyceae) benthic bloom in Southwestern Indian Ocean, Journal of Phycology, vol.40, issue.6, pp.1042-1051, 2004.

R. J. Lewis, QDPI research on ciguatera, Bulletin La ciguatera, vol.1, p.5, 1991.

S. Li, H. Shen, L. Zhu, J. Xu, X. Jia et al., Ultra-high-performance liquid chromatographyquadrupole/time of flight mass spectrometry based chemical profiling approach to rapidly reveal chemical transformation of sulfur-fumigated medicinal herbs, a case study on white ginseng, Journal of Chromatography A, vol.1231, pp.31-45, 2012.

X. Li, Z. Li, J. Chen, Q. Shi, R. Zhang et al., Detection, occurrence and monthly variations of typical lipophilic marine toxins associated with diarrhetic shellfish poisoning in the coastal seawater of Qingdao City, China. Chemosphere, vol.111, pp.560-567, 2014.

C. L. Lin, Y. J. Wu, W. F. Lin, C. H. Hsieh, Y. L. Hsieh et al., Seasonal characteristics and tetrodotoxin-producing ability of bacteria in gastropod Oliva hirasei, Hydrobiologia, vol.741, issue.1, pp.23-32, 2014.

M. C. Louzao, I. R. Ares, and E. Cagide, Marine toxins and the cytoskeleton: a new view of palytoxin toxicity, The FEBS Journal, vol.275, issue.24, pp.6067-6074, 2008.

W. Lu, B. D. Bennett, and J. D. Rabinowitz, Analytical strategies for LC-MS-based targeted metabolomics, Journal of Chromatography B, vol.871, issue.2, pp.236-242, 2008.

L. Mackenzie, P. Holland, P. Mcnabb, V. Beuzenberg, A. Selwood et al., Complex toxin profiles in phytoplankton and Greenshell mussels (Perna canaliculus), revealed by LC-MS/MS analysis, Toxicon, vol.40, issue.9, pp.1321-1330, 2002.

S. L. Mackinnon, J. A. Walter, M. A. Quilliam, A. D. Cembella, P. Leblanc et al., Spirolides isolated from Danish strains of the toxigenic dinoflagellate Alexandrium ostenfeldii, Journal of Natural Products, vol.69, issue.7, pp.983-987, 2006.

M. Maeda, T. Kodama, T. Tanaka, Y. Ohfune, K. Nomoto et al., Insecticidal and Neuromuscular Activities of Domoic Acid and Its Related Compounds, Journal of Pesticide Science, vol.9, issue.1, pp.27-32, 1984.

Y. L. Mak, T. C. Wai, M. B. Murphy, W. H. Chan, J. J. Wu et al., Pacific ciguatoxins in food web components of coral reef systems in the republic of kiribati, Environ Sci Technol, vol.47, issue.24, pp.14070-14079, 2013.

A. Makarov, Electrostatic Axially Harmonic Orbital Trapping: A High-Performance Technique of Mass Analysis, Analytical Chemistry, vol.72, issue.6, pp.1156-1162, 2000.

R. Marrouchi, Les spirolides : une famille de toxines émergentes qui contaminent les mollusques bivalves, Toxines et fonctions cholinergiques neuronales et non neuronales, pp.13-17, 2008.

I. Martinez, J. D. Loréal, and H. , Application of modern analytical techniques to ensure seafood safety and authenticity, 2005.

M. Mattarozzi, F. Bianchi, M. Milioli, A. Cavazza, and M. Careri, An innovative method based on quick, easy, cheap, effective, rugged, and safe extraction coupled to desorption electrospray ionization-high resolution mass spectrometry for screening the presence of paralytic shellfish toxins in clams, Talanta, vol.147, pp.416-421, 2016.

M. Mattarozzi, M. Milioli, F. Bianchi, A. Cavazza, S. Pigozzi et al., Optimization of a rapid QuEChERS sample treatment method for HILIC-MS2 analysis of paralytic shellfish poisoning (PSP) toxins in mussels, Food Control, vol.60, pp.138-145, 2016.

P. Mccarron, W. A. Rourke, W. Hardstaff, B. Pooley, and M. A. Quilliam, Identification of pinnatoxins and discovery of their fatty acid ester metabolites in mussels (mytilus edulis) from eastern Canada, Journal of Agricultural and Food Chemistry, vol.60, issue.6, pp.1437-1446, 2012.

P. Mccarron, E. Wright, and M. A. Quilliam, Liquid chromatography/mass spectrometry of domoic acid and lipophilic shellfish toxins with selected reaction monitoring and optional confirmation by library searching of product ion spectra, Journal of AOAC International, vol.97, issue.2, pp.316-324, 2014.

P. Mcnabb, A. I. Selwood, and P. T. Holland, Multiresidue method for determination of algal toxins in shellfish: Single-laboratory validation and interlaboratory study, Journal of AOAC International, vol.88, issue.3, pp.761-772, 2005.

P. Mcnabb, A. I. Selwood, R. Munday, S. A. Wood, D. I. Taylor et al., Detection of tetrodotoxin from the grey side-gilled sea slug -Pleurobranchaea maculata, and associated dog neurotoxicosis on beaches adjacent to the Hauraki Gulf, Toxicon, vol.56, issue.3, pp.466-473, 2010.

P. S. Mcnabb, A. I. Selwood, R. Van-ginkel, M. Boundy, and P. T. Holland, Determination of brevetoxins in shellfish by LC/MS/MS: Single-laboratory validation, Journal of AOAC International, vol.95, issue.4, pp.1097-1105, 2012.

D. Mebs, O. Arakawa, and M. Yotsu-yamashita, Tissue distribution of tetrodotoxin in the redspotted newt Notophthalmus viridescens, Toxicon, vol.55, issue.7, pp.1353-1357, 2010.

C. O. Miles, I. A. Samdal, J. A. Aasen, D. J. Jensen, M. A. Quilliam et al., Evidence for numerous analogs of yessotoxin in Protoceratium reticulatum, Harmful Algae, vol.4, issue.6, pp.1075-1091, 2005.

C. O. Miles, A. L. Wilkins, R. Munday, M. H. Dines, A. D. Hawkes et al., Isolation of pectenotoxin-2 from Dinophysis acuta and its conversion to pectenotoxin-2 seco acid, and preliminary assessment of their acute toxicities, Toxicon, vol.43, issue.1, pp.1-9, 2004.

C. O. Miles, A. L. Wilkins, D. J. Stirling, and A. L. Mackenzie, New analogue of gymnodimine from a Gymnodinium species, Journal of Agricultural and Food Chemistry, vol.48, issue.4, pp.1373-1376, 2000.

C. O. Miles, A. L. Wilkins, D. J. Stirling, and A. L. Mackenzie, Gymnodimine C, an isomer of gymnodimine B, from Karenia selliformis, Journal of Agricultural and Food Chemistry, vol.51, issue.16, pp.4838-4840, 2003.

F. Mondeguer, La métabolomique et les biotoxines marines. Anses -Bulletin de veille scientifique 29, vol.5, 2015.

M. Murata, M. Kumagai, J. S. Lee, and T. Yasumoto, Isolation and structure of yessotoxin, a novel polyether compound implicated in diarrhetic shellfish poisoning, Tetrahedron Letters, vol.28, issue.47, pp.5869-5872, 1987.

M. Murata, M. Shimatani, H. Sugitani, Y. Oshima, and T. Yasumoto, Isolation and structural elucidation of the causative toxin of the diarrhetic shellfish poisoning, Bull. Jpn. Soc. Sci. Fish, vol.48, pp.549-552, 1982.

J. S. Murray, M. J. Boundy, A. I. Selwood, and D. T. Harwood, Development of an LC-MS/MS method to simultaneously monitor maitotoxins and selected ciguatoxins in algal cultures and P-CTX-1B in fish, Harmful Algae, vol.80, pp.80-87, 2018.

J. P. Naar, L. J. Flewelling, A. Lenzi, J. P. Abbott, A. Granholm et al., Brevetoxins, like ciguatoxins, are potent ichthyotoxic neurotoxins that accumulate in fish, Toxicon, vol.50, issue.5, pp.707-723, 2007.

T. Narahashi, H. G. Haas, and E. F. Therrien, Saxitoxin and tetrodotoxin: Comparison of nerve blocking mechanism, Science, vol.157, issue.3795, pp.1438-1440, 1967.

E. Nézan and N. Chomérat, Vulcanodinium rugosum gen. et sp. nov. (Dinophyceae), un Nouveau Dinoflagellé Marin de la Côte Méditerranéenne Française, Cryptogamie, Algologie, vol.32, issue.1, pp.3-18, 2011.

J. Nicolas, R. L. Hoogenboom, P. J. Hendriksen, M. Bodero, T. F. Bovee et al., Marine biotoxins and associated outbreaks following seafood consumption: Prevention and surveillance in the 21st century, Global Food Security, vol.15, pp.11-21, 2017.

L. T. Nielsen, P. J. Hansen, B. Krock, and B. Vismann, Accumulation, transformation and breakdown of DSP toxins from the toxic dinoflagellate Dinophysis acuta in blue mussels, Toxicon, vol.117, pp.84-93, 2016.

T. Nonomura, M. Sasaki, N. Matsumori, M. Murata, K. Tachibana et al., The Complete Structure of Maitotoxin, Part II: Configuration of the C135 C142 Side Chain and Absolute Configuration of the Entire Molecule, Angewandte Chemie International Edition in English, vol.35, issue.15, pp.1675-1678, 1996.

A. Nozawa, K. Tsuji, and H. Ishida, Implication of brevetoxin B1 and PbTx-3 in neurotoxic shellfish poisoning in New Zealand by isolation and quantitative determination with liquid chromatography-tandem mass spectrometry, Toxicon, vol.42, issue.1, pp.91-103, 2003.

Y. Onuma, M. Satake, T. Ukena, J. Roux, S. Chanteau et al., Identification of putative palytoxin as the cause of clupeotoxism, Toxicon, vol.37, issue.1, pp.55-65, 1999.

G. Orellana, J. Vanden-bussche, L. Van-meulebroek, M. Vandegehuchte, C. Janssen et al., Validation of a confirmatory method for lipophilic marine toxins in shellfish using UHPLC-HR-Orbitrap MS, Analytical and Bioanalytical Chemistry, vol.406, issue.22, pp.5303-5312, 2014.

A. Otero, M. Chapela, M. Atanassova, J. M. Vieites, and A. G. Cabado, Cyclic Imines: Chemistry and Mechanism of Action: A Review, Chemical Research in Toxicology, vol.24, issue.11, pp.1817-1829, 2011.

O. Pardo, V. Yusà, N. León, and A. Pastor, Development of a pressurised liquid extraction and liquid chromatography with electrospray ionization-tandem mass spectrometry method for the determination of domoic acid in shellfish, Journal of Chromatography A, vol.1154, issue.1, pp.287-294, 2007.

I. Paredes, I. M. Rietjens, J. M. Vieites, and A. G. Cabado, Update of risk assessments of main marine biotoxins in the European Union, Toxicon, vol.58, issue.4, pp.336-354, 2011.

J. Patocka, R. C. Gupta, Q. H. Wu, and K. Kuca, Toxic potential of palytoxin, Journal of Huazhong University of Science and Technology -Medical Science, vol.35, issue.5, pp.773-780, 2015.

B. Paz, P. Riobó, M. Luisa-fernández, S. Fraga, and J. M. Franco, Production and release of yessotoxins by the dinoflagellates Protoceratium reticulatum and Lingulodinium polyedrum in culture, Toxicon, vol.44, issue.3, pp.251-258, 2004.

M. Pelin, V. Brovedani, S. Sosa, and A. Tubaro, Palytoxin-containing aquarium soft corals as an emerging sanitary problem, Marine Drugs, vol.14, issue.2, 2016.

H. Pereira, J. Martin, C. Joly, J. Sébédio, and E. Pujos-guillot, Development and validation of a UPLC/MS method for a nutritional metabolomic study of human plasma, Metabolomics, vol.6, issue.2, pp.207-218, 2010.

T. M. Perl, J. Teitelbaum, J. Hockin, and E. C. Todd, Domoic acid toxicity. Panel discussion: definition of the syndrome, Canada diseases weekly report 16 Suppl 1E, pp.41-45, 1990.

R. H. Pierce and M. S. Henry, Harmful algal toxins of the Florida red tide (Karenia brevis): Natural chemical stressors in South Florida coastal ecosystems, Ecotoxicology, vol.17, issue.7, pp.623-631, 2008.

G. C. Pitcher, A. D. Cembella, L. B. Joyce, J. Larsen, T. A. Probyn et al., The dinoflagellate Alexandrium minutum in Cape Town harbour (South Africa): Bloom characteristics, phylogenetic analysis and toxin composition, Harmful Algae, vol.6, issue.6, pp.823-836, 2007.

S. M. Plakas and R. W. Dickey, Advances in monitoring and toxicity assessment of brevetoxins in molluscan shellfish, Toxicon, vol.56, issue.2, pp.137-149, 2010.

S. Poyer, C. Loutelier-bourhis, G. Coadou, F. Mondeguer, J. Enche et al., Identification and separation of saxitoxins using hydrophilic interaction liquid chromatography coupled to traveling wave ion mobility-mass spectrometry, Journal of Mass Spectrometry, vol.50, issue.1, pp.175-181, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01107931

M. A. Quilliam, Recent developments in the analysis of phycotoxins by liquid chromatography-mass spectrometry. Mycotoxins and phycotoxins, Proceedings of the Xth International IUPAC Symposium on Guaruja, pp.383-391, 2001.

M. A. Quilliam, The role of chromatography in the hunt for red tide toxins, Journal of Chromatography A, vol.1000, issue.1-2, pp.527-548, 2003.

V. Ramos and V. Vasconcelos, Palytoxin and Analogs: Biological and Ecological Effects, Marine Drugs, vol.8, issue.7, p.2021, 2010.

J. Regueiro, G. Álvarez, A. Mauriz, and J. Blanco, High throughput analysis of amnesic shellfish poisoning toxins in bivalve molluscs by dispersive solid-phase extraction and high-performance liquid chromatography using a monolithic column, Food Chemistry, vol.127, issue.4, pp.1884-1891, 2011.

J. Regueiro, A. E. Rossignoli, G. Álvarez, and J. Blanco, Automated on-line solid-phase extraction coupled to liquid chromatography-tandem mass spectrometry for determination of lipophilic marine toxins in shellfish, Food Chemistry, vol.129, issue.2, pp.533-540, 2011.

B. Reguera, P. Riobó, F. Rodríguez, P. A. Díaz, G. Pizarro et al., Dinophysis toxins: Causative organisms, distribution and fate in shellfish, Marine Drugs, vol.12, issue.1, pp.394-461, 2014.

N. Rehmann, P. Hess, and M. A. Quilliam, Discovery of new analogs of the marine biotoxin azaspiracid in blue mussels (Mytilus edulis) by ultra-performance liquid chromatography/tandem mass spectrometry, Rapid Communications in Mass Spectrometry, vol.22, issue.4, pp.549-558, 2008.

L. Rhodes, A. Selwood, P. Mcnabb, L. Briggs, J. Adamson et al., Trace metal effects on the production of biotoxins by microalgae, African Journal of Marine Science, vol.28, issue.2, pp.393-397, 2006.

D. Richard, E. Arsenault, A. Cembella, and M. Quilliam, Investigations into the toxicology and pharmacology of spirolides -a novel group of putative biotoxins, Harmful Algal Blooms, pp.383-387, 2000.

A. Robertson, A. C. Garcia, H. A. Quintana, T. B. Smith, B. F. Ii et al., Invasive Lionfish (Pterois volitans): A Potential Human Health Threat for Ciguatera Fish Poisoning in Tropical Waters, Mar Drugs, vol.12, issue.1, pp.88-97, 2013.

A. Robertson, D. Stirling, C. Robillot, L. Llewellyn, and A. Negri, First report of saxitoxin in octopi, Toxicon, vol.44, issue.7, pp.765-771, 2004.

L. P. Rodríguez, V. González, A. Martínez, B. Paz, J. Lago et al., Occurrence of lipophilic marine toxins in shellfish from Galicia (NW of Spain) and synergies among them, Marine Drugs, vol.13, issue.4, pp.1666-1687, 2015.

P. Rodriguez, A. Alfonso, C. Vale, C. Alfonso, P. Vale et al., First Toxicity Report of Tetrodotoxin and 5,6,11-TrideoxyTTX in the Trumpet Shell Charonia lampas lampas in Europe, Analytical Chemistry, vol.80, issue.14, pp.5622-5629, 2008.

K. Roeder, K. Erler, S. Kibler, P. Tester, H. Van-the et al., Characteristic profiles of Ciguatera toxins in different strains of Gambierdiscus spp, Toxicon, vol.56, issue.5, pp.731-738, 2010.

G. Ronzitti, P. Hess, N. Rehmann, and G. P. Rossini, Azaspiracid-1 Alters the E-cadherin Pool in Epithelial Cells, Toxicological Sciences, vol.95, issue.2, pp.427-435, 2007.

R. Rossi, V. Castellano, E. Scalco, L. Serpe, A. Zingone et al., New palytoxin-like molecules in Mediterranean Ostreopsis cf. ovata (dinoflagellates) and in Palythoa tuberculosa detected by liquid chromatography-electrospray ionization time-of-flight mass spectrometry, Toxicon, vol.56, issue.8, pp.1381-1387, 2010.

A. Rúbies, E. Muñoz, D. Gibert, N. Cortés-francisco, M. Granados et al., New method for the analysis of lipophilic marine biotoxins in fresh and canned bivalves by liquid chromatography coupled to high resolution mass spectrometry: A quick, easy, cheap, efficient, rugged, safe approach, Journal of Chromatography A, vol.1386, pp.62-73, 2015.

T. Rundberget, J. A. Aasen, A. I. Selwood, and C. O. Miles, Pinnatoxins and spirolides in Norwegian blue mussels and seawater, Toxicon, vol.58, issue.8, pp.700-711, 2011.

C. Ruttkies, E. L. Schymanski, S. Wolf, J. Hollender, and S. Neumann, MetFrag relaunched: incorporating strategies beyond in silico fragmentation, Journal of Cheminformatics, vol.8, issue.1, p.3, 2016.

M. Satake, T. Ichimura, K. Sekiguchi, S. Yoshimatsu, and Y. Oshima, 47-trinoryessotoxin production by protoceratium reticulatum collected in Japan, Natural Toxins, vol.45, issue.4, pp.147-150, 1999.

E. J. Schantz, Studies on shellfish poisons, Journal of Agricultural and Food Chemistry, vol.17, issue.3, pp.413-416, 1969.

C. Schmitt, R. Torrents, B. Domangé, M. Glaizal, N. Simon et al., Palytoxin poisoning with soft coral from a tank in France: 3 cases reports, Presse Med, vol.47, issue.2, pp.178-180, 2018.
URL : https://hal.archives-ouvertes.fr/inserm-02101282

E. L. Schymanski, H. P. Singer, J. Slobodnik, I. M. Ipolyi, P. Oswald et al., Non-target screening with high-resolution mass spectrometry: critical review using a collaborative trial on water analysis, Analytical and Bioanalytical Chemistry, vol.407, issue.21, pp.6237-6255, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02601318

T. Seki, M. Satake, L. Mackenzie, H. F. Kaspar, and T. Yasumoto, Gymnodimine, a new marine toxin of unprecedented structure isolated from New Zealand oysters and the dinoflagellate, Gymnodinium sp, Tetrahedron Letters, vol.36, issue.39, pp.7093-7096, 1995.

A. I. Selwood, C. O. Miles, A. L. Wilkins, R. Van-ginkel, R. Munday et al., Isolation, Structural Determination and Acute Toxicity of Pinnatoxins E, F and G, Journal of Agricultural and Food Chemistry, vol.58, issue.10, pp.6532-6542, 2010.

A. I. Selwood, R. Van-ginkel, D. T. Harwood, P. S. Mcnabb, L. R. Rhodes et al., A sensitive assay for palytoxins, ovatoxins and ostreocins using LC-MS/MS analysis of cleavage fragments from micro-scale oxidation, Toxicon, vol.60, issue.5, pp.810-820, 2012.

A. I. Selwood, A. L. Wilkins, R. Munday, F. Shi, L. L. Rhodes et al., Portimine: A bioactive metabolite from the benthic dinoflagellate Vulcanodinium rugosum, Tetrahedron Letters, vol.54, issue.35, pp.4705-4707, 2013.

S. E. Shumway and T. L. Cucci, The effects of the toxic dinoflagellate Protogonyaulax tamarensis on the feeding and behaviour of bivalve molluscs, Aquatic Toxicology, vol.10, issue.1, pp.9-27, 1987.

M. Sibat, C. Herrenknecht, H. T. Darius, M. Roué, M. Chinain et al., Detection of pacific ciguatoxins using liquid chromatography coupled to either low or high resolution mass spectrometry (LC-MS/MS), Journal of Chromatography A, vol.1571, pp.16-28, 2018.

M. Silva, V. K. Pratheepa, L. M. Botana, and V. Vasconcelos, Emergent toxins in north Atlantic temperate waters: A challenge for monitoring programs and legislation, Toxins, vol.7, issue.3, pp.859-885, 2015.

M. Silva, I. Rodriguez, A. Barreiro, M. Kaufmann, A. I. Neto et al., First report of ciguatoxins in two starfish species: Ophidiaster ophidianus and Marthasterias glacialis, Toxins, vol.7, issue.9, pp.3740-3757, 2015.

L. Sleno, A. J. Windust, and D. A. Volmer, Structural study of spirolide marine toxins by mass spectrometry: Part I. Fragmentation pathways of 13-desmethyl spirolide C by collisioninduced dissociation and infrared multiphoton dissociation mass spectrometry, Analytical and Bioanalytical Chemistry, vol.378, issue.4, pp.969-976, 2004.

C. A. Smith, E. J. Want, G. O'maille, R. Abagyan, and G. Siuzdak, XCMS: Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment, Matching, and Identification, Analytical Chemistry, vol.78, issue.3, pp.779-787, 2006.

H. Sommer and K. F. Meyer, Paralytic Shell-Fish Poisoning, Arch. Pathol, vol.24, pp.560-598, 1937.

O. B. Stabell, I. Steffenak, and T. Aune, An evaluation of the mouse bioassay applied to extracts of 'diarrhoetic' shellfish toxins, Food and Chemical Toxicology, vol.30, issue.2, pp.139-144, 1992.

I. Stewart, G. K. Eaglesham, S. Poole, G. Graham, C. Paulo et al., Establishing a public health analytical service based on chemical methods for detecting and quantifying Pacific ciguatoxin in fish samples, Toxicon, vol.56, issue.5, pp.804-812, 2010.

I. Stewart and C. Mcleod, The Laboratory Mouse in Routine Food Safety Testing for Marine Algal Biotoxins and Harmful Algal Bloom Toxin Research: Past, Present and Future, JOURNAL OF AOAC INTERNATIONAL, vol.97, issue.2, pp.356-372, 2014.

Z. Su, M. Sheets, H. Ishida, F. Li, and W. H. Barry, Saxitoxin Blocks L-Type ICa, Journal of Pharmacology and Experimental Therapeutics, vol.308, issue.1, pp.324-329, 2004.

B. Suarez-gomez, M. L. Souto, M. Norte, and J. J. Fernandez, Isolation and structural determination of DTX-6, a new okadaic acid derivative, Journal of Natural Products, vol.64, issue.10, pp.1363-1364, 2001.

M. Suehiro, Historical review on chemical and medical studies of globefish toxin before World War II, 1994.

, Yakushigaku Zasshi, vol.29, issue.3, pp.428-434

T. Suzuki, V. Beuzenberg, L. Mackenzie, and M. A. Quilliam, Liquid chromatography-mass spectrometry of spiroketal stereoisomers of pectenotoxins and the analysis of novel pectenotoxin isomers in the toxic dinoflagellate Dinophysis acuta from New Zealand, Journal of Chromatography A, vol.992, issue.1-2, pp.141-150, 2003.

T. Suzuki, H. Uchida, and R. Watanabe, Comprehensive Analytical Chemistry -Recent Advances in the Analysis of Marine Toxins, p.43, 2017.

K. Tachibana, P. J. Scheuer, Y. Tsukitani, H. Kikuchi, D. Van-engen et al., Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria, Journal of the American Chemical Society, vol.103, issue.9, pp.2469-2471, 1981.

N. Takada, N. Umemura, K. Suenaga, and D. Uemura, Structural determination of pteriatoxins A, B and C, extremely potent toxins from the bivalve Pteria penguin, Tetrahedron Letters, vol.42, issue.20, pp.3495-3497, 2001.

T. Takemoto and K. Daigo, Constituents of Chondria armata, Chemical and Pharmaceutical Bulletin, vol.6, issue.5, pp.578-580, 1958.

L. Tartaglione, C. Dellaversano, A. Mazzeo, M. Forino, A. Wieringa et al., Determination of Palytoxins in Soft Coral and Seawater from a Home Aquarium. Comparison between Palythoa-and Ostreopsis-Related Inhalatory Poisonings, Environmental Science and Technology, vol.50, issue.2, pp.1023-1030, 2016.

L. Tartaglione, M. Pelin, M. Morpurgo, C. Dell'aversano, J. Montenegro et al., An aquarium hobbyist poisoning: Identification of new palytoxins in Palythoa cf. toxica and complete detoxification of the aquarium water by activated carbon, Toxicon, vol.121, pp.41-50, 2016.

E. Tengstrand, J. Rosén, K. Hellenäs, and K. M. Åberg, A concept study on non-targeted screening for chemical contaminants in food using liquid chromatography-mass spectrometry in combination with a metabolomics approach, Analytical and Bioanalytical Chemistry, vol.405, issue.4, pp.1237-1243, 2013.

A. These, C. Klemm, I. Nausch, and S. Uhlig, Results of a European interlaboratory method validation study for the quantitative determination of lipophilic marine biotoxins in raw and cooked shellfish based on high-performance liquid chromatography-tandem mass spectrometry. Part I: Collaborative study, Analytical and Bioanalytical Chemistry, vol.399, issue.3, pp.1245-1256, 2011.

Y. Tikunov, A. Lommen, C. H. De-vos, H. A. Verhoeven, R. J. Bino et al., A Novel Approach for Nontargeted Data Analysis for Metabolomics. Large-Scale Profiling of Tomato Fruit Volatiles, Plant Physiology, vol.139, issue.3, pp.1125-1137, 2005.

D. R. Tindall, R. W. Dickey, R. D. Carlson, and G. Morey-gaines, Ciguatoxic dinoflagellates from the Caribbean sea, sea food toxins, pp.225-240, 1984.

T. Torgersen, N. B. Bremnes, T. Rundberget, and T. Aune, Structural confirmation and occurrence of azaspiracids in Scandinavian brown crabs (Cancer pagurus), Toxicon, vol.51, issue.1, pp.93-101, 2008.

A. Tubaro, S. Sosa, G. Altinier, M. R. Soranzo, M. Satake et al., Short-term oral toxicity of homoyessotoxins, yessotoxin and okadaic acid in mice, Toxicon, vol.43, issue.4, pp.439-445, 2004.

A. D. Turner, M. Dhanji-rapkova, L. Coates, L. Bickerstaff, S. Milligan et al., Detection of Tetrodotoxin Shellfish Poisoning (TSP) toxins and causative factors in bivalve molluscs from the UK, Marine Drugs, vol.15, issue.9, 2017.

A. D. Turner, C. Higgins, K. Davidson, A. Veszelovszki, D. Payne et al., Potential threats posed by new or emerging marine biotoxins in UK waters and examination of detection methodology used in their control: Brevetoxins, Marine Drugs, vol.13, issue.3, pp.1224-1254, 2015.

A. D. Turner, C. Higgins, W. Higman, and J. Hungerford, Potential threats posed by tetrodotoxins in UK waters: Examination of detection methodology used in their control, Marine Drugs, vol.13, issue.12, pp.7357-7376, 2015.

A. D. Turner, P. S. Mcnabb, D. T. Harwood, A. I. Selwood, and M. J. Boundy, Single-laboratory validation of a multitoxin ultra-performance LC-hydrophilic interaction LC-MS/MS method for quantitation of paralytic shellfish toxins in bivalve shellfish, Journal of AOAC International, vol.98, issue.3, pp.609-621, 2015.

E. Turrell, L. Stobo, J. P. Lacaze, S. Piletsky, and E. Piletska, Optimization of hydrophilic interaction liquid chromatography/mass spectrometry and development of solid-phase extraction for the determination of paralytic shellfish poisoning toxins, Journal of AOAC International, vol.91, issue.6, pp.1372-1386, 2008.

M. Twiner, N. Rehmann, P. Hess, and G. Doucette, Azaspiracid Shellfish Poisoning: A Review on the Chemistry, Ecology, and Toxicology with an Emphasis on Human Health Impacts, Marine Drugs, vol.6, issue.2, p.39, 2008.

P. Vale, M. J. Botelho, S. M. Rodrigues, S. S. Gomes, and M. A. Sampayo, Two decades of marine biotoxin monitoring in bivalves from Portugal (1986-2006): A review of exposure assessment, Harmful Algae, vol.7, issue.1, pp.11-25, 2008.

H. J. Van-den-top, A. Gerssen, P. Mccarron, and H. P. Van-egmond, Quantitative determination of marine lipophilic toxins in mussels, oysters and cockles using liquid chromatographymass spectrometry: Inter-laboratory validation study. Food Additives and Contaminants -Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, vol.28, issue.12, pp.1745-1757, 2011.

F. M. Van-dolah, Marine algal toxins: Origins, health effects, and their increased occurrence, Environmental Health Perspectives, vol.108, pp.133-141, 2000.

N. Vilariño, M. C. Louzao, P. Abal, E. Cagide, C. Carrera et al., Human poisoning from marine toxins: Unknowns for optimal consumer protection, Toxins, vol.10, issue.8, 2018.

N. Vilariño, M. C. Louzao, M. Fraga, L. P. Rodríguez, and L. M. Botana, Innovative detection methods for aquatic algal toxins and their presence in the food chain, Analytical and Bioanalytical Chemistry, vol.405, issue.24, pp.7719-7732, 2013.

P. Visciano, M. Schirone, M. Berti, A. Milandri, R. Tofalo et al., Marine Biotoxins: Occurrence, Toxicity, Regulatory Limits and Reference Methods. Front Microbiol 7, p.1051, 2016.

Z. Wang, J. Maucher-fuquay, S. E. Fire, C. M. Mikulski, B. Haynes et al., Optimization of solid-phase extraction and liquid chromatography-tandem mass spectrometry for the determination of domoic acid in seawater, phytoplankton, and mammalian fluids and tissues, Analytica Chimica Acta, vol.715, pp.71-79, 2012.

S. M. Watkins, A. Reich, L. E. Fleming, and R. Hammond, Neurotoxic shellfish poisoning, Marine Drugs, vol.6, issue.3, pp.431-455, 2008.

E. Werner, J. Heilier, C. Ducruix, E. Ezan, C. Junot et al., Mass spectrometry for the identification of the discriminating signals from metabolomics: Current status and future trends, Journal of Chromatography B, vol.871, issue.2, pp.143-163, 2008.

M. Wiese, P. M. D'agostino, T. K. Mihali, M. C. Moffitt, and B. A. Neilan, Neurotoxic Alkaloids: Saxitoxin and Its Analogs, Marine Drugs, vol.8, issue.7, p.2185, 2010.

I. D. Wilson, R. Plumb, J. Granger, H. Major, R. Williams et al., HPLC-MS-based methods for the study of metabonomics, Journal of Chromatography B, vol.817, issue.1, pp.67-76, 2005.

S. Wold, K. Esbensen, and P. Geladi, Principal component analysis, Chemometrics and Intelligent Laboratory Systems, vol.2, issue.1, pp.37-52, 1987.

C. K. Wong, P. Hung, and J. Y. Lo, Ciguatera fish poisoning in Hong Kong-A 10-year perspective on the class of ciguatoxins, Toxicon, vol.86, pp.96-106, 2014.

J. L. Wright, R. K. Boyd, A. S. De-freitas, M. Falk, R. A. Foxall et al., Identification of domoic acid a neuroexcitatory amino acid in toxic mussels from eastern prince edward island canada, CAN J CHEM, vol.67, issue.3, pp.481-490, 1989.

C. H. Wu, Palytoxin: Membrane mechanisms of action, Toxicon, vol.54, issue.8, pp.1183-1189, 2009.

H. Wu, M. Guo, Z. Tan, H. Cheng, Z. Li et al., Liquid chromatography quadrupole linear ion trap mass spectrometry for multiclass screening and identification of lipophilic marine biotoxins in bivalve mollusks, Journal of Chromatography A, vol.1358, pp.172-180, 2014.

J. J. Wu, Y. L. Mak, M. B. Murphy, J. C. Lam, W. H. Chan et al., Validation of an accelerated solvent extraction liquid chromatography-tandem mass spectrometry method for Pacific ciguatoxin-1 in fish flesh and comparison with the mouse neuroblastoma assay, Anal Bioanal Chem, vol.400, issue.9, pp.3165-3175, 2011.

Y. Wu, C. Lin, C. Chen, C. Hsieh, H. Jen et al., Toxin and species identification of toxic octopus implicated into food poisoning in Taiwan, Toxicon, vol.91, pp.96-102, 2014.

M. Xiao, H. Chen, Z. Shi, Y. Feng, and W. Rui, Rapid and reliable method for analysis of raw and honey-processed astragalus by UPLC/ESI-Q-TOF-MS using HSS T3 columns, Analytical Methods, vol.6, issue.19, pp.8045-8054, 2014.

H. Xin and R. Stone, Chinese Probe Unmasks High-Tech Adulteration With Melamine, Science, vol.322, issue.5906, pp.1310-1311, 2008.

N. Yasumoto and M. , Marine Toxins Produced by Marine Dinoflagellates, Biol Bull, vol.172, pp.128-131, 1987.

T. Yasumoto, Recent progress in the chemistry of dinoflagellate toxins, pp.259-270, 1985.

T. Yasumoto, T. Igarashi, A. Legrand, P. Cruchet, M. Chinain et al., structural elucidation of ciguatoxin congeners by fast-atom bombardment tandem mass spectrometry, J AM CHEM SOC, vol.122, issue.20, pp.4988-4989, 2000.

T. Yasumoto and M. Murata, Marine toxins, Chemical Reviews, vol.93, issue.5, pp.1897-1909, 1993.

K. Yogi, N. Oshiro, Y. Inafuku, M. Hirama, and T. Yasumoto, Detailed LC-MS/MS Analysis of Ciguatoxins Revealing Distinct Regional and Species Characteristics in Fish and Causative Alga from the Pacific, Analytical Chemistry, vol.83, issue.23, pp.8886-8891, 2011.

K. Yogi, S. Sakugawa, N. Oshiro, T. Ikehara, K. Sugiyama et al., Determination of toxins involved in ciguatera fish poisoning in the Pacific by LC/MS, J AOAC Int, vol.97, issue.2, pp.398-402, 2014.

L. Zaman, O. Arakawa, A. Shimosu, Y. Onoue, S. Nishio et al., Two new isomers of domoic acid from a red alga, Chondria armata, Toxicon, vol.35, issue.2, pp.205-212, 1997.

Z. Zendong, S. Bertrand, C. Herrenknecht, E. Abadie, C. Jauzein et al., Passive Sampling and High Resolution Mass Spectrometry for Chemical Profiling of French Coastal Areas with a Focus on Marine Biotoxins, Environmental Science and Technology, vol.50, issue.16, pp.8522-8529, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01925508

Z. Zendong, P. Mccarron, C. Herrenknecht, M. Sibat, Z. Amzil et al., High resolution mass spectrometry for quantitative analysis and untargeted screening of algal toxins in mussels and passive samplers, Journal of Chromatography A, vol.1416, pp.10-21, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01664180

A. Zhang, H. Sun, and X. Wang, Serum metabolomics as a novel diagnostic approach for disease: A systematic review, Analytical and Bioanalytical Chemistry, vol.404, issue.4, pp.1239-1245, 2012.

Y. Zhang, D. Chen, and Z. Hong, A rapid LC-HRMS method for the determination of domoic acid in urine using a self-assembly pipette tip solid-phase extraction, Toxins, vol.8, issue.1, 2015.

Y. Zhao, L. Zhang, F. Long, X. Cheng, X. Bai et al., UPLC-Q-TOF/HSMS/MSE-based metabonomics for adenine-induced changes in metabolic profiles of rat faeces and intervention effects of ergosta-4, Chemico-Biological Interactions, vol.6, issue.14, pp.31-38, 2013.

L. Zhuo, W. Fu, Y. Yang, B. Qiu, Z. Lin et al., Simultaneous determination of biotoxins DSP and AZAs in bivalve molluscs and fish by liquid chromatography/tandem mass spectrometry, Rapid Communications in Mass Spectrometry, vol.28, issue.13, pp.1479-1488, 2014.

L. Zhuo, Y. Yin, W. Fu, B. Qiu, Z. Lin et al., Determination of paralytic shellfish poisoning toxins by HILIC-MS/MS coupled with dispersive solid phase extraction, Food Chemistry, vol.137, issue.1-4, pp.115-121, 2013.