Skip to Main content Skip to Navigation
Theses

Copolymères amphiphiles supramoléculaires pour l'encapsulation déclenchable de composés

Abstract : The encapsulation and triggerable release of actives display numerous benefits and are used in complex formulations designed for various applications. In this thesis, we show that supramolecular chemistry enables the design of amphiphilic copolymers, capable to encapsulate lipophilic compounds, dispersed in aqueous solution.The goal of this work was to develop and characterize encapsulating objects formed by amphiphilic supramolecular copolymers, inspired by non ionic, commercially available emulsifiers, Pluronics®.As a first step, we synthesized amphiphilic supramolecular copolymers. Associative and complementary units thymine (Thy) and diaminotriazine (DAT), which are largely studied in supramolecular materials subjects, were grafted by a one-step reaction, at the end(s) of poly(ethylene) glycol chains, hydrophilic, and poly(propylene) glycol chains, hydrophobic. Both initial chains are commercially available (Jeffamine®). The two supramolecular units associate selectively by 3 parallel hydrogen bonds, enabling the formation of amphiphilic copolymers. Their self-assembly in a selective solvent, like water, or in a aqueous biphasic mixture, lead to the formation of encapsulating objects, which are designed for a cosmetic application.Strength and stability of Thy/DAT supramolecular bon was investigated in water and in different organic solvents. Objects formed by the self-assembly of the supramolecular copolymers were also characterized by the mean of several techniques. Use of amphiphilic supramolecular copolymers was found conclusive for the stabilization of direct emulsions, formed by spontaneous emulsification (Ouzo effect). Thus, proof on concept was established, emulsions being seen as the encapsulation of a lipophilic compound in an aqueous phase (liquid-liquid dispersion).
Document type :
Theses
Complete list of metadatas

https://pastel.archives-ouvertes.fr/tel-03081141
Contributor : Abes Star :  Contact
Submitted on : Friday, December 18, 2020 - 9:28:20 AM
Last modification on : Saturday, December 19, 2020 - 3:39:02 AM

File

ESPCI_Maissa-HadoFARROUX_2018....
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-03081141, version 1

Collections

Citation

Maïssa-Hado Farroux. Copolymères amphiphiles supramoléculaires pour l'encapsulation déclenchable de composés. Matériaux. Université Paris sciences et lettres, 2018. Français. ⟨NNT : 2018PSLET042⟩. ⟨tel-03081141⟩

Share

Metrics

Record views

20

Files downloads

10