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Microfluidique papier pour le diagnostic de terrain : préparation d'échantillon et multiplexage

Abstract : Since the Ebola outbreak of 2014, the MMN Laboratory and the Pasteur Institute are working to conduct molecular biology tests on paper microfluidics for the diagnosis of infectious diseases. Tests made in Guinée in 2015, by the two teams, have shown the pertinence of the technology. Today, both teams are working on developing a multiplexed devices (simultaneous detection of multiple biological targets). The recent Zika Virus (ZIKV) outbreak transmitted by Aedes mosquitoes in geographic area where other arboviruses such as Dengue (DENV) and Chikungunya (CHIKV) were already spreading focused the development work on a Zika/Dengue/Chikungunya multiplexed test. The first goal is to get a point of care device, cheap and easy to use allowing a better management of the patients. The development of such a device would then be used by Pasteur Institut network to monitor more precisely the epidemiology of those diseases displaying the same the same symptomatology, and study the physiology of their co-infection.
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Submitted on : Friday, March 19, 2021 - 9:23:09 AM
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Pierre Garneret. Microfluidique papier pour le diagnostic de terrain : préparation d'échantillon et multiplexage. Mécanique [physics]. Université Paris sciences et lettres, 2019. Français. ⟨NNT : 2019PSLET072⟩. ⟨tel-03174261⟩

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