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Les petits ARN non codants du spermatozoïde bovin : de potentiels biomarqueurs de la fertilité mâle ?

Abstract : Most dairy cows are inseminated and sub-fertile bulls can have an overall dramatic negative impact on the sustainability of the dairy sector. The bull fertility prediction, through efficient quality control (QC) procedures is thus crucial for the cattle breeding sector. Over the last decades, several biomarkers and quality control procedures have been proposed to guarantee semen fertility, including assessment of key functional parameters using flow cytometry. However, their relevance for routine QC has yet to be ascertained and their predictive value is too limited to confidently discard subfertile bulls. Thus, studies have been conducted by LabCom SeQuaMol to explore to what extent the bull sperm epigenome may be relevant to improve fertility prediction. In this respect, this PhD thesis was focused on small noncoding RNAs (sncRNAs), which have been shown to play a role in spermatogenesis and fertilization. We aimed at improving the scientific knowledge on bull sperm sncRNA content in order to develop a routine tool to predict bull fertility. The work has been organized according to three main themes: providing a comprehensive overview of cattle sperm sncRNA, studying their expression dynamics during sperm maturation along epididymis and identifying biomarkers associated with bull fertility.
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Submitted on : Monday, May 10, 2021 - 4:10:43 PM
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  • HAL Id : tel-03223078, version 1

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Eli Sellem. Les petits ARN non codants du spermatozoïde bovin : de potentiels biomarqueurs de la fertilité mâle ?. Biologie de la reproduction. Université Paris-Saclay, 2021. Français. ⟨NNT : 2021UPASB008⟩. ⟨tel-03223078⟩

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