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Mécanismes d'action de complexes polypyridyle du Ruthénium (II) utilisés comme agents chimiothérapeutiques ou photosensibilisateurs pour la photothérapie dynamique

Abstract : Nowadays chemotherapy is the most common therapy used to treat cancer. Currently employed drugs are not ideal, and there is a need for new chemotherapeutics. Photodynamic therapy (PDT) is a succesful alternative or complimentary treatment to chemotherapy, radiotherapy and surgery. This medical technique involves non-toxic photosensitiser (PS) which after irradiation with specific and defined wavelenght can react with molecular oxygen or other biological substrates. As a result very reactive oxygen species or radicals are created, leading to impairment of metabolic pathways and eventually to cell death. Ru(II) polypyridyl complexes are promising chemotherapeutics as well as photosensitisers for PDT. Aim of this thesis is to understand how Ru(II)complexes excert their action in living cells. Understanding mechanisms in which photosensitizers or chemotherpeutics are acting is an important step in designing new, better compounds suitable for chemotherapy and/or for PDT.
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Submitted on : Tuesday, May 11, 2021 - 2:28:23 PM
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Marta Jakubaszek. Mécanismes d'action de complexes polypyridyle du Ruthénium (II) utilisés comme agents chimiothérapeutiques ou photosensibilisateurs pour la photothérapie dynamique. Chimie thérapeutique. Université Paris sciences et lettres, 2020. Français. ⟨NNT : 2020UPSLC001⟩. ⟨tel-03224177⟩

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