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Modélisation de la dynamique des corps lipidiques chez Arabidopsis thaliana

Abstract : The aim of the PhD project is to dissect the mechanisms involved in the phenotype of lipid droplets both at the cellular level and the seed level. Studying a model of a lipid droplet embedded in the leaflets of a lipid bilayer reveals the existence of a critical volume at which the shape of the droplet breaks from a symmetrical elongated lens to a spherical protrusion. This budding mechanisms provides new insights in the formation of lipid droplets. Segmentation and tracking of lipid droplets from timelapse confocal microscopy images allows the detection of lipid droplets fusion events. A method based on the conservation of volume during the fusion event is developed and applied to detect fusion events for several embryos of A. thaliana. A model of the coalescence of lipid droplets during the development of early A. thaliana embryos is developed. The fusion rate is estimated and compared in different wild type and mutant embryos. The estimation is based on lipid droplets volumes measured from images at different stages of the development of the embryos.
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Submitted on : Tuesday, June 8, 2021 - 3:56:08 PM
Last modification on : Friday, July 16, 2021 - 2:02:57 PM


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  • HAL Id : tel-03254115, version 1


François Deslandes. Modélisation de la dynamique des corps lipidiques chez Arabidopsis thaliana. Systèmes dynamiques [math.DS]. Université Paris Saclay (COmUE), 2017. Français. ⟨NNT : 2017SACLA042⟩. ⟨tel-03254115⟩



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