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Fractionation and characterization of nanoparticles by a hydrodynamic method : modelling and application to consumer products

Abstract : Due to the increasing use of nanoparticles, a better understanding of their properties, their environmental fate, and their impact on the human health becomes mandatory. To this end, reliable methods for the characterization of nanomaterials’ properties need to be developed. Among the different properties of nanoparticles, the size is particularly important as it influences several other properties (e.g. the reactivity, the toxicity or their behavior in the environment). The asymmetrical flow field flow (AF4) is a technique that fractionates the different populations inside the sample as a function of their hydrodynamic diameter. In the 1960s, a model (thereafter called classical model) relying the retention time of a nanoparticle with its hydrodynamic diameter has been developed. However, the model validity is based on work hypothesizes which are not always respected depending on the experimental conditions.The work of this PhD thesis has consisted firstly in the study of the mechanisms governing the nanoparticles retention inside the AF4 channel. Notably it has been shown that interactions between the nanoparticles and the accumulation wall of the AF4 biased the results predicted by the classical model. Another model (thereafter called p-w model), which takes electrostatic and Van de Walls interactions into account, has been developed. Tests realized with particle standards for size showed that the p-w model give results with a better trueness than the classical model and that it can be applied for a larger range of experimental conditions. A validation of this model has been conducted and an uncertainty budget has been developed by following the Monte Carlo method. The metrological traceability of the measurement results has also been demonstrated.
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Submitted on : Monday, August 16, 2021 - 3:03:09 PM
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Valentin de Carsalade Du Pont. Fractionation and characterization of nanoparticles by a hydrodynamic method : modelling and application to consumer products. Physics [physics]. Université Paris sciences et lettres, 2021. English. ⟨NNT : 2021UPSLS045⟩. ⟨tel-03320831⟩

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