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Catalyse au cobalt : applications en couplages croisés et en activation/fonctionnalisation de liaison C-H

Abstract : Organic synthesis has been making outstanding recent progress because of the use of transition-metal catalysis into laboratory routine. Among different metals involved in catalysis, cobalt is interesting because of its low cost and toxicity but also because of its unique reactivity.During this thesis, cross-coupling and C—H bond activation reactions using cobalt complexes as catalysts were investigated.A simple catalytic system composed of diphosphine ligand and a cost-effective cobalt salt allowed us to functionnalize α-haloamides using Grignard reagents. A large variety of amides and Grignard reagents (aryl-, vinyl-, alkynyl-) were successfully tested, generating an interesting library of α-functionnalized amides.Moreover, simple cobalt salts were engaged in the activation of the C—H bond of benzamides for the aminoarylation of alkylidene cyclopropanes. Under mild conditions, original and polycyclic molecules were obtained in a single step.These results obtained in two different domains treated in this thesis demonstrate the high potential of simple cobalt salt in catalysis.
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Etienne Barde. Catalyse au cobalt : applications en couplages croisés et en activation/fonctionnalisation de liaison C-H. Chimie organique. Université Paris sciences et lettres, 2018. Français. ⟨NNT : 2018PSLET019⟩. ⟨tel-03362688⟩

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