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Theses

Développement d'outils et de méthodes de sélection génomique chez le bar et la daurade

Abstract : European seabass (Dicentrarchus labrax) and gilthead seabream (Sparus aurata) are two major species of Mediterranean aquaculture. As any animal production, aquaculture must face many disease outbreaks leading to high mortality, that can be controlled by selective breeding. With easy access to whole genome sequencing technologies and genomic tools, the use of genomic data in selective breeding has to be considered. The purpose of this thesis was to develop tools and methods to implement genomic selection to improve resistance to viral nervous necrosis and vibriosis in seabass and to pasteurellosis in seabream.First, we developed a simple and efficient parentage assignment tool based on a method using Mendelian transmission probabilities, estimated from the population of offspring to assign. Then, we studied the genetic architecture of the traits by variance components estimation and QTL detection. We showed that the viral nervous necrosis resistance in seabass is an oligogenic traitcontrolled by a strong effect QTL with a moderate heritability. We also showed that resistance to vibriosis in seabass and to pasteurellosis in seabream are two polygenic traits with moderate heritability. Finally, we evaluated the accuracy of genomic selection with different marker densities and different training population sizes, using or not the information on the viral nervous necrosis resistance QTL in seabass. We showed that genomic selection increased selection accuracy by 8.9% to 24.5% in the species and traits we studied. Then, we showed that accounting of the viral nervous necrosis resistance QTL information in seabass increased selection accuracy by 10.5% to 26.3%.This thesis evaluated the efficiency of the genomic selection in seabass and seabream, and develop tools making the use of genomic data in breeding schemes easier. Thus, we now have a framework to implement and optimize the genomic selection in seabass and seabream.
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https://pastel.archives-ouvertes.fr/tel-03429983
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Submitted on : Tuesday, November 16, 2021 - 8:24:11 AM
Last modification on : Friday, August 5, 2022 - 2:38:11 PM
Long-term archiving on: : Thursday, February 17, 2022 - 6:09:53 PM

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  • HAL Id : tel-03429983, version 1

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Ronan Griot. Développement d'outils et de méthodes de sélection génomique chez le bar et la daurade. Génétique animale. Université Paris-Saclay, 2021. Français. ⟨NNT : 2021UPASB010⟩. ⟨tel-03429983⟩

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