Skip to Main content Skip to Navigation
Theses

Analyse prospective et biomécanique de la marche et des déformations osseuses chez les patients atteints de rachitisme hypophosphatémique lié au chromosome X

Abstract : X-linked hypophosphatemic rickets (XLH) is a rare disease affecting the musculoskeletal system and lower limb function. Most of the symptoms of XLH have a strong impact on the daily life of patients but can be minimized during growth with adapted treatment. To date, only a qualitative assessment of the physical symptoms of XLH is possible. This thesis aims to define a protocol for the quantitative evaluation of XLH and its evolution during growth for the lower limbs. The first part deals with the 3D study of the skeleton. It shows that the femoral shaft is particularly affected. In follow-up we see that the mechanical angles normalize first under the effect of the treatment, the femur and the tibia evolving together. A second part focusing on the quantitative gait analysis shows that the alterations mainly concern the frontal plane and that they are linked to bone deformities. A final part, dealing with muscles, highlights an alteration in composition and muscle atrophy in patients with XLH which may explain the muscle weakness observed. By combining these three examinations, the protocol proposed in this thesis makes it possible both to quantify the alterations of the musculoskeletal system and of gait in children with XLH and to improve our understanding of the existing interactions between these three elements.
Complete list of metadata

https://pastel.archives-ouvertes.fr/tel-03682676
Contributor : ABES STAR :  Contact
Submitted on : Tuesday, May 31, 2022 - 11:33:10 AM
Last modification on : Friday, August 5, 2022 - 2:54:01 PM

File

bonnetlebrun.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-03682676, version 1

Citation

Aurore Bonnet-Lebrun. Analyse prospective et biomécanique de la marche et des déformations osseuses chez les patients atteints de rachitisme hypophosphatémique lié au chromosome X. Biomécanique [physics.med-ph]. HESAM Université, 2021. Français. ⟨NNT : 2021HESAE050⟩. ⟨tel-03682676⟩

Share

Metrics

Record views

45

Files downloads

27